Publications

Carmena M, Wheelock M, Funabiki H, Earnshaw WC. The chromosomal passenger complex (CPC): from easy rider to the godfather of mitosis.Nat Rev Mol Cell Biol. 2012 Dec;13(12):789-803. doi: 10.1038/nrm3474. Review. PMID: 23175282; FREE ARTICLE

 

Samejima K, Samejima I, Vagnarelli P, Ogawa H, Vargiu G, Kelly DA, de Lima Alves F, Kerr A, Green LC, Hudson DF, Ohta S, Cooke CA, Farr CJ, Rappsilber J, Earnshaw WC. Mitotic chromosomes are compacted laterally by KIF4 and condensin and axially by topoisimerase IIa.J Cell Biol. 2012 Nov 26;199(5):755-70. doi: 10.1083/jcb.201202155. PMID: 23166350; FREE ARTICLE

 

Kouprina N, Earnshaw WC, Masumoto H, Larionov V. A new generation of human artificial chromosomes for functional genomics and gene therapy. Cell Mol Life Sci. 2013 Apr;70(7):1135-48. doi: 10.1007/s00018-012-1113-3. Epub 2012 Aug 21. Review. PMID: 22907415; FREE ARTICLE

 

Bergmann JH, Martins NM, Larionov V, Masumoto H, Earnshaw WC. HACking the centromere chromatin code: insights from human artificial chromosomes. Chromosome Res. 2012 Jul; 20(5):505-19. doi: 10.1007/s10577-012-9293-0. Review. PMID: 22825423.

 

Ohzeki JI, Bergmann JH, Kouprina N, Noskov VN, Nakano M, Kimura H, Earnshaw WC, Larionov V, Masumoto H. Breaking the HAC Barrier: Histone H3K9 acetyl/methyl balance regulates CENP-A assembly. EMBO J. 2012 May 16;31(10):2391-402. doi: 10.1038/emboj.2012.82. Epub 2012 Apr 3.PubMed PMID: 22473132; FREE ARTICLE

 

Vagnarelli P, Earnshaw WC. Repo-Man-PP1: a link between chromatin remodelling and nuclear envelope reassembly. Nucleus. 2012 Mar 1;3(2):138-42. doi: 10.4161/nucl.19267. Epub 2012 Mar 1. Review. PMID: 22555598; FREE ARTICLE

 

Green LC, Kalitsis P, Chang TM, Cipetic M, Kim JH, Marshall O, Turnbull L, Whitchurch CB, Vagnarelli P, Samejima K, Earnshaw WC, Choo KH, Hudson DF. Contrasting roles of condensin I and II in mitotic chromosome formation. J Cell Sci. 2012 Mar 15;125(Pt 6):1591-1604. Epub 2012 Feb 17. PubMed PMID: 22344259.

 

Bergmann JH, Jakubsche JN, Martins NM, Kagansky A, Nakano M, Kimura H, Kelly DA, Turner BM, Masumoto H, Larionov V, Earnshaw WC. Epigenetic engineering: histone H3K9 acetylation is compatible with kinetochore structure and function. J Cell Sci. 2012 Jan 15;125(Pt 2):411-21. Epub 2012 Feb 13. PubMed PMID: 22331359.

 

Carmena M, Pinson X, Platani M, Salloum Z, Xu Z, Clark A, Macisaac F, Ogawa H, Eggert U, Glover DM, Archambault V, Earnshaw WC. The chromosomal passenger complex activates Polo kinase at centromeres. PLoS Biol. 2012 Jan;10(1):e1001250. Epub 2012 Jan 24. PubMed PMID: 22291575FREE ARTICLE

 

Kim JH, Kononenko A, Erliandri I, Kim TA, Nakano M, Iida Y, Barrett JC, Oshimura M, Masumoto H, Earnshaw WC, Larionov V, Kouprina N. Human artificial chromosome (HAC) vector with a conditional centromere for correction of genetic deficiencies in human cells. Proc Natl Acad Sci U S A. 2011 Dec 13;108(50):20048-53. Epub 2011 Nov 28. PubMed PMID: 22123967FREE ARTICLE

 

Flors C, Earnshaw WC. Super-resolution fluorescence microscopy as a tool to study the nanoscale organization of chromosomes. Curr Opin Chem Biol. 2011 Dec;15(6):838-44. Epub 2011 Nov 16. Review. PubMed PMID: 22098720.

 

Vagnarelli P, Ribeiro S, Sennels L, Sanchez-Pulido L, de Lima Alves F, Verheyen T, Kelly DA, Ponting CP, Rappsilber J, Earnshaw WC. Repo-Man coordinates chromosomal reorganization with nuclear envelope reassembly during mitotic exit. Dev Cell. 2011 Aug 16;21(2):328-42. Epub 2011 Aug 4. PubMed PMID: 21820363.

 

Ohta S, Bukowski-Wills JC, Wood L, de Lima Alves F, Chen Z, Rappsilber J, Earnshaw WC. Proteomics of isolated mitotic chromosomes identifies the kinetochore protein Ska3/Rama1. Cold Spring Harb Symp Quant Biol. 2010;75:433-8. Epub 2011 Feb 2. PubMed PMID: 21289047.

 

Bergmann JH, Rodriguez MG, Martins NM, Kimura H, Kelly DA, Masumoto H, Larionov V, Jansen LE, Earnshaw WC. Epigenetic engineering shows H3K4me2 is required for HJURP targeting and CENP-A assembly on a synthetic human kinetochore. EMBO J. 2011 Jan 19;30(2):328-40. Epub 2010 Dec 14. PubMed PMID: 21157429FREE ARTICLE

 

Fant X, Samejima K, Carvalho A, Ogawa H, Xu Z, Yue Z, Earnshaw WC, Ruchaud S. Use of DT40 conditional-knockout cell lines to study chromosomal passenger protein function. Biochem Soc Trans. 2010 Dec;38(6):1655-9. PubMed PMID: 21118143.

 

Ohta S, Wood L, Bukowski-Wills JC, Rappsilber J, Earnshaw WC. Building mitotic chromosomes. Curr Opin Cell Biol. 2011 Feb;23(1):114-21. Epub 2010 Oct 23. Review. PubMed PMID: 20974528; FREE ARTICLE

 

Xu Z, Vagnarelli P, Ogawa H, Samejima K, Earnshaw WC. Gradient of increasing  Aurora B kinase activity is required for cells to execute mitosis. J Biol Chem. 2010 Dec 17;285(51):40163-70. Epub 2010 Oct 18. PubMed PMID: 20956539; FREE ARTICLE

 

Ohta S, Bukowski-Wills JC, Sanchez-Pulido L, Alves Fde L, Wood L, Chen ZA, Platani M, Fischer L, Hudson DF, Ponting CP, Fukagawa T, Earnshaw WC, Rappsilber J. The protein composition of mitotic chromosomes determined using multiclassifier combinatorial proteomics. Cell. 2010 Sep 3;142(5):810-21. PubMed PMID: 20813266; FREE ARTICLE

 

Iida Y, Kim JH, Kazuki Y, Hoshiya H, Takiguchi M, Hayashi M, Erliandri I, Lee
HS, Samoshkin A, Masumoto H, Earnshaw WC, Kouprina N, Larionov V, Oshimura M. Human artificial chromosome with a conditional centromere for gene delivery and gene expression. DNA Res. 2010 Oct;17(5):293-301. Epub 2010 Aug 26. PubMed PMID: 20798231; FREE ARTICLE

 

Fernandez-Miranda G, Perez de Castro I, Carmena M, Aguirre-Portoles C, Ruchaud S, Fant X, Montoya G, Earnshaw WC, Malumbres M. SUMOylation modulates the function of Aurora-B kinase. J Cell Sci. 2010 Aug 15;123(Pt 16):2823-33. Epub 2010 Jul 27. PubMed PMID: 20663916; FREE ARTICLE

 

Ribeiro SA, Vagnarelli P, Dong Y, Hori T, McEwen BF, Fukagawa T, Flors C, Earnshaw WC. A super-resolution map of the vertebrate kinetochore. Proc Natl Acad Sci U S A. 2010 Jun 8;107(23):10484-9. Epub 2010 May 18. PubMed PMID: 20483991; FREE ARTICLE

 

Patzlaff JS, Terrenoire E, Turner BM, Earnshaw WC, Paulson JR. Acetylation of core histones in response to HDAC inhibitors is diminished in mitotic HeLa cells. Exp Cell Res. 2010 Aug 1;316(13):2123-35. Epub 2010 May 7. PubMed PMID: 20452346; FREE ARTICLE

 

Xu Z, Ogawa H, Vagnarelli P, Bergmann JH, Hudson DF, Ruchaud S, Fukagawa T, Earnshaw WC, Samejima K. INCENP-aurora B interactions modulate kinase activity and chromosome passenger complex localization. J Cell Biol. 2009 Nov 30;187(5):637-53. Erratum in: J Cell Biol. 2010 Feb 22;188(4):611. PubMed PMID: 19951914; FREE ARTICLE

 

Carmena M, Ruchaud S, Earnshaw WC. Making the Auroras glow: regulation of Aurora A and B kinase function by interacting proteins. Curr Opin Cell Biol. 2009 Dec;21(6):796-805. Review. PubMed PMID: 19836940; FREE ARTICLE

 

Cardinale S, Bergmann JH, Kelly D, Nakano M, Valdivia MM, Kimura H, Masumoto  H, Larionov V, Earnshaw WC. Hierarchical inactivation of a synthetic human kinetochore by a chromatin modifier. Mol Biol Cell. 2009 Oct;20(19):4194-204. Epub 2009 Aug 5. PubMed PMID: 19656847; FREE ARTICLE

 

Hudson DF, Marshall KM, Earnshaw WC. Condensin: Architect of mitotic chromosomes. Chromosome Res. 2009;17(2):131-44. Review. PubMed PMID: 19308696.

 

Ribeiro SA, Gatlin JC, Dong Y, Joglekar A, Cameron L, Hudson DF, Farr CJ, McEwen BF, Salmon ED, Earnshaw WC, Vagnarelli P. Condensin regulates the stiffness of vertebrate centromeres. Mol Biol Cell. 2009 May;20(9):2371-80. Epub 2009 Mar 4. PubMed PMID: 19261808; FREE ARTICLE

 

Zhou L, Li J, George R, Ruchaud S, Zhou HG, Ladbury JE, Earnshaw WC, Yuan X.  Effects of full-length borealin on the composition and protein-protein interaction activity of a binary chromosomal passenger complex. Biochemistry. 2009 Feb 17;48(6):1156-61. PubMed PMID: 19146389; FREE ARTICLE

 

Yue Z, Carvalho A, Xu Z, Yuan X, Cardinale S, Ribeiro S, Lai F, Ogawa H, Gudmundsdottir E, Gassmann R, Morrison CG, Ruchaud S, Earnshaw WC. Deconstructing Survivin: comprehensive genetic analysis of Survivin function by conditional knockout in a vertebrate cell line. J Cell Biol. 2008 Oct 20;183(2):279-96. PubMed PMID: 18936249; FREE ARTICLE

 

Tadeu AM, Ribeiro S, Johnston J, Goldberg I, Gerloff D, Earnshaw WC. CENP-V is required for centromere organization, chromosome alignment and cytokinesis. EMBO J. 2008 Oct 8;27(19):2510-22. Epub 2008 Sep 4. PubMed PMID: 18772885; FREE ARTICLE

 

Colombie N, Cullen CF, Brittle AL, Jang JK, Earnshaw WC, Carmena M, McKim K, Ohkura H. Dual roles of Incenp crucial to the assembly of the acentrosomal metaphase spindle in female meiosis. Development. 2008 Oct;135(19):3239-46. Epub 2008 Aug 28. PubMed PMID: 18755775; FREE ARTICLE

 

Hudson DF, Ohta S, Freisinger T, Macisaac F, Sennels L, Alves F, Lai F, Kerr A, Rappsilber J, Earnshaw WC. Molecular and genetic analysis of condensin function in vertebrate cells. Mol Biol Cell. 2008 Jul;19(7):3070-9. Epub 2008 May 14. PubMed PMID: 18480406; FREE ARTICLE

 

Vagnarelli P, Ribeiro SA, Earnshaw WC. Centromeres: old tales and new tools. FEBS Lett. 2008 Jun 18;582(14):1950-9. Epub 2008 Apr 22. Review. PubMed PMID: 18435926.

 

Nakano M, Cardinale S, Noskov VN, Gassmann R, Vagnarelli P, Kandels-Lewis S, Larionov V, Earnshaw WC, Masumoto H. Inactivation of a human kinetochore by specific targeting of chromatin modifiers. Dev Cell. 2008 Apr;14(4):507-22. PubMed PMID: 18410728; FREE ARTICLE

 

Kaufmann SH, Lee SH, Meng XW, Loegering DA, Kottke TJ, Henzing AJ, Ruchaud S, Samejima K, Earnshaw WC. Apoptosis-associated caspase activation assays. Methods. 2008 Mar;44(3):262-72. Review. PubMed PMID: 18314058.

 

Samejima K, Ogawa H, Cooke CA, Hudson DF, Macisaac F, Ribeiro SA, Vagnarelli P, Cardinale S, Kerr A, Lai F, Ruchaud S, Yue Z, Earnshaw WC. A promoter-hijack strategy for conditional shutdown of multiply spliced essential cell cycle genes. Proc Natl Acad Sci U S A. 2008 Feb 19;105(7):2457-62. Epub 2008 Feb 8. Erratum in: Proc Natl Acad Sci U S A. 2008 Apr 8;105(14):5650. Hudson, Damien [Hudson, Damien F]. PubMed PMID: 18263736; FREE ARTICLE

 

Griffith E, Walker S, Martin CA, Vagnarelli P, Stiff T, Vernay B, Al Sanna N, Saggar A, Hamel B, Earnshaw WC, Jeggo PA, Jackson AP, O'Driscoll M. Mutations in pericentrin cause Seckel syndrome with defective ATR-dependent DNA damage signaling. Nat Genet. 2008 Feb;40(2):232-6. Epub 2007 Dec 23. PubMed PMID: 18157127; FREE ARTICLE

 

Ruchaud S, Carmena M, Earnshaw WC. The chromosomal passenger complex: one for all and all for one. Cell. 2007 Oct 19;131(2):230-1. PubMed PMID: 17956723.

 

Ruchaud S, Carmena M, Earnshaw WC. Chromosomal passengers: conducting cell division. Nat Rev Mol Cell Biol. 2007 Oct;8(10):798-812. Review. PubMed PMID: 17848966.

 

Tone S, Sugimoto K, Tanda K, Suda T, Uehira K, Kanouchi H, Samejima K, Minatogawa Y, Earnshaw WC. Three distinct stages of apoptotic nuclear condensation revealed by time-lapse imaging, biochemical and electron microscopy analysis of cell-free apoptosis. Exp Cell Res. 2007 Oct 1;313(16):3635-44. Epub 2007 Jul 4. PubMed PMID: 17643424; FREE ARTICLE

 

Ageichik AV, Samejima K, Kaufmann SH, Earnshaw WC. Genetic analysis of the short splice variant of the inhibitor of caspase-activated DNase (ICAD-S) in chicken DT40 cells. J Biol Chem. 2007 Sep 14;282(37):27374-82. Epub 2007 Jul 6. PubMed PMID: 17616520. FREE ARTICLE

 

Faragher AJ, Sun XM, Butterworth M, Harper N, Mulheran M, Ruchaud S, Earnshaw WC, Cohen GM. Death receptor-induced apoptosis reveals a novel interplay between the chromosomal passenger complex and CENP-C during interphase. Mol Biol Cell. 2007 Apr;18(4):1337-47. Epub 2007 Feb 7. PubMed PMID: 17287400; FREE ARTICLE

 

Zachos G, Black EJ, Walker M, Scott MT, Vagnarelli P, Earnshaw WC, Gillespie DA. Chk1 is required for spindle checkpoint function. Dev Cell. 2007 Feb;12(2):247-60. PubMed PMID: 17276342.

 

Rodriguez-Bayona B, Ruchaud S, Rodriguez C, Linares M, Astola A, Ortiz M, Earnshaw WC, Valdivia MM. Autoantibodies against the chromosomal passenger protein INCENP found in a patient with Graham Little-Piccardi-Lassueur syndrome.  J Autoimmune Dis. 2007 Jan 12;4:1. PubMed PMID: 17222351; FREE ARTICLE

older publications