Publications

Booth DG, Beckett AJ, Molina O, Samejima I, Masumoto H, Kouprina N, Larionov V, Prior IA, Earnshaw WC. 3D-CLEM Reveals that a Major Portion of Mitotic Chromosomes Is Not Chromatin. Mol Cell. 2016 Nov 17;64(4):790-802. doi: 10.1016/j.molcel.2016.10.009. Epub 2016 Nov 10. PMID: 27840028; FREE ARTICLE

 

Ohzeki J, Shono N, Otake K, Martins NM, Kugou K, Kimura H, Nagase T, Larionov V, Earnshaw WC, Masumoto H. KAT7/HBO1/MYST2 Regulates CENP-A Chromatin Assembly by Antagonizing Suv39h1-Mediated Centromere Inactivation. Dev Cell. 2016 Jun 6;37(5):413-27. doi: 10.1016/j.devcel.2016.05.006. PMID: 27270040; FREE ARTICLE

 

Ohta S, Montaño-Gutierrez LF, de Lima Alves F, Ogawa H, Toramoto I, Sato N, Morrison CG, Takeda S, Hudson DF, Rappsilber J, Earnshaw WC. Proteomics Analysis with a Nano Random Forest Approach Reveals Novel Functional Interactions Regulated by SMC Complexes on Mitotic Chromosomes. Mol Cell Proteomics. 2016 Aug;15(8):2802-18. doi: 10.1074/mcp.M116.057885. Epub 2016 May 26. PMID: 27231315; FREE ARTICLE

 

Kim JH, Lee HS, Lee NC, Goncharov NV, Kumeiko V, Masumoto H, Earnshaw WC, Kouprina N, Larionov V. Development of a novel HAC-based "gain of signal" quantitative assay for measuring chromosome instability (CIN) in cancer cells. Oncotarget. 2016 Mar 22;7(12):14841-56. doi: 10.18632/oncotarget.7854. PMID: 26943579; FREE ARTICLE

 

Wood L, Booth DG, Vargiu G, Ohta S, deLima Alves F, Samejima K, Fukagawa T, Rappsilber J, Earnshaw WC. Auxin/AID versus conventional knockouts: distinguishing the roles of CENP-T/W in mitotic kinetochore assembly and stability. Open Biol. 2016 Jan;6(1):150230. doi: 10.1098/rsob.150230. PMID: 26791246; FREE ARTICLE

 

Samejima I, Spanos C, Alves Fde L, Hori T, Perpelescu M, Zou J, Rappsilber J, Fukagawa T, Earnshaw WC. Whole-proteome genetic analysis of dependencies in assembly of a vertebrate kinetochore. J Cell Biol. 2015 Dec 21;211(6):1141-56. doi: 10.1083/jcb.201508072. Epub 2015 Dec 14. PMID: 26668330; FREE ARTICLE

 

Carmena M, Earnshaw WC, Glover DM. The Dawn of Aurora Kinase Research: From Fly Genetics to the Clinic. Front Cell Dev Biol. 2015 Nov 17;3:73. doi: 10.3389/fcell.2015.00073. eCollection 2015. PMID: 26636082; FREE ARTICLE

 

Martins NM, Bergmann JH, Shono N, Kimura H, Larionov V, Masumoto H, Earnshaw WC. Epigenetic engineering shows that a human centromere resists silencing mediated by H3K27me3/K9me3. Mol Biol Cell. 2016 Jan 1;27(1):177-96. doi: 10.1091/mbc.E15-08-0605. Epub 2015 Nov 12. PMID: 26564795; FREE ARTICLE

 

Shono N, Ohzeki J, Otake K, Martins NM, Nagase T, Kimura H, Larionov V, Earnshaw WC, Masumoto H. CENP-C and CENP-I are key connecting factors for kinetochore and CENP-A assembly. J Cell Sci. 2015 Dec 15;128(24):4572-87. doi: 10.1242/jcs.180786. Epub 2015 Nov 2. PMID: 26527398; FREE ARTICLE

 

González-Loyola A, Fernández-Miranda G, Trakala M, Partida D, Samejima K, Ogawa H, Cañamero M, de Martino A, Martínez-Ramírez Á, de Cárcer G, Pérez de Castro I, Earnshaw WC, Malumbres M. Aurora B Overexpression Causes Aneuploidy and p21Cip1 Repression during Tumor Development. Mol Cell Biol. 2015 Oct;35(20):3566-78. doi: 10.1128/MCB.01286-14. Epub 2015 Aug 3. PMID: 26240282; FREE ARTICLE

 

Samejima K, Platani M, Wolny M, Ogawa H, Vargiu G, Knight PJ, Peckham M, Earnshaw WC. The Inner Centromere Protein (INCENP) Coil Is a Single α-Helix (SAH) Domain That Binds Directly to Microtubules and Is Important for Chromosome Passenger Complex (CPC) Localization and Function in Mitosis. J Biol Chem. 2015 Aug 28;290(35):21460-72. doi: 10.1074/jbc.M115.645317. Epub 2015 Jul 14. PMID: 26175154; FREE ARTICLE

 

Papini D, Langemeyer L, Abad MA, Kerr A, Samejima I, Eyers PA, Jeyaprakash AA, Higgins JM, Barr FA, Earnshaw WC. TD-60 links RalA GTPase function to the CPC in mitosis. Nat Commun. 2015 Jul 9;6:7678. doi: 10.1038/ncomms8678. PMID: 26158537; FREE ARTICLE

 

Platani M, Trinkle-Mulcahy L, Porter M, Jeyaprakash AA, Earnshaw WC. Mio depletion links mTOR regulation to Aurora A and Plk1 activation at mitotic centrosomes. J Cell Biol. 2015 Jul 6;210(1):45-62. doi: 10.1083/jcb.201410001. Epub 2015 Jun 29. PMID: 26124292; FREE ARTICLE

 

Earnshaw WC. Discovering centromere proteins: from cold white hands to the A, B, C of CENPs. Nat Rev Mol Cell Biol. 2015 Jul;16(7):443-9. doi: 10.1038/nrm4001. Epub 2015 May 20. PMID: 25991376

 

Xavier de Carvalho A, Maiato H, Maia AF, Ribeiro SA, Pontes P, Bickmore W, Earnshaw WC, Sambade C. Reed-Sternberg cells form by abscission failure in the presence of functional Aurora B kinase. PLoS One 2015 May 1;10(5):e0124629. doi: 10.1371/journal.pone.0124629. eCollection 2015. PMID: 25933052; FREE ARTICLE

 

Barysz H, Kim JH, Chen ZA, Hudson DF, Rappsilber J, Gerloff DL, Earnshaw WC. Three-dimensional topology of the SMC2/SMC4 subcomplex from chicken condensin I revealed by cross-linking and molecular modelling. Open Biol. 2015 Feb;5(2):150005. doi: 10.1098/rsob.150005. PMID: 25716199; FREE ARTICLE

 

Kononenko AV, Lee NC, Liskovykh M, Masumoto H, Earnshaw WC, Larionov V, Kouprina N. Generation of a conditionally self-eliminating HAC gene delivery vector through incorporation of a tTAVP64 expression cassette. Nucleic Acids Res. 2015 May 19;43(9):e57. doi: 10.1093/nar/gkv124. Epub 2015 Feb 20. PMID: 25712097; FREE ARTICLE

 

Ohzeki J, Larionov V, Earnshaw WC, Masumoto H. Genetic and epigenetic regulation of centromeres: a look at HAC formation. Chromosome Res. 2015 Feb;23(1):87-103. doi: 10.1007/s10577-015-9470-z. PMID: 25682171

 

Ohta S, Wood L, Toramoto I, Yagyu K, Fukagawa T, Earnshaw WC. CENP-32 is required to maintain centrosomal dominance in bipolar spindle assembly. Mol Biol Cell. 2015 Apr 1;26(7):1225-37. doi: 10.1091/mbc.E14-09-1366. Epub 2015 Feb 5. PMID: 25657325; FREE ARTICLE

 

Castonguay E, White SA, Kagansky A, St-Cyr DJ, Castillo AG, Brugger C, White R, Bonilla C, Spitzer M, Earnshaw WC, Schalch T, Ekwall K, Tyers M, Allshire RC. Panspecies small-molecule disruptors of heterochromatin-mediated transcriptional gene silencing. Mol Cell Biol. 2015 Feb;35(4):662-74. doi: 10.1128/MCB.01102-14. Epub 2014 Dec 8. PMID: 25487573; FREE ARTICLE

 

Gohard FH, St-Cyr DJ, Tyers M, Earnshaw WC. Targeting the INCENP IN-box-Aurora B interaction to inhibit CPC activity in vivo. Open Biol. 2014 Nov;4(11):140163. doi: 10.1098/rsob.140163. PMID: 25392451; FREE ARTICLE

 

Carmena M, Lombardia MO, Ogawa H, Earnshaw WC. Polo kinase regulates the localization and activity of the chromosomal passenger complex in meiosis and mitosis in Drosophila melanogaster. Open Biol. 2014 Nov;4(11):140162. doi: 10.1098/rsob.140162. PMID: 25376909; FREE ARTICLE

 

Fukagawa T, Earnshaw WC. Neocentromeres. Curr Biol. 2014 Oct 6;24(19):R946-7. doi: 10.1016/j.cub.2014.08.032. PMID: 25291631; FREE ARTICLE

 

Kononenko AV, Bansal R, Lee NC, Grimes BR, Masumoto H, Earnshaw WC, Larionov V, Kouprina N. A portable BRCA1-HAC (human artificial chromosome) module for analysis of BRCA1 tumor suppressor function. Nucleic Acids Res. 2014 Dec 1;42(21). doi: 10.1093/nar/gku870. Epub 2014 Sep 26. PMID: 25260588; FREE ARTICLE

 

Samejima K, Ogawa H, Ageichik AV, Peterson KL, Kaufmann SH, Kanemaki MT, Earnshaw WC. Auxin-induced rapid degradation of inhibitor of caspase-activated DNase (ICAD) induces apoptotic DNA fragmentation, caspase activation, and cell death: a cell suicide module. J Biol Chem. 2014 Nov 7;289(45):31617-23. doi: 10.1074/jbc.M114.583542. Epub 2014 Sep 23. PMID: 25248749; FREE ARTICLE

 

Erliandri I, Fu H, Nakano M, Kim JH, Miga KH, Liskovykh M, Earnshaw WC, Masumoto H, Kouprina N, Aladjem MI, Larionov V. Replication of alpha-satellite DNA arrays in endogenous human centromeric regions and in human artificial chromosome. Nucleic Acids Res. 2014 Oct;42(18):11502-16. doi: 10.1093/nar/gku835. Epub 2014 Sep 16. PMID: 25228468; FREE ARTICLE

 

Fukagawa T, Earnshaw WC. The centromere: chromatin foundation for the kinetochore machinery. Dev Cell. 2014 Sep 8;30(5):496-508. doi: 10.1016/j.devcel.2014.08.016. PMID: 25203206; FREE ARTICLE

 

Hori T, Shang WH, Toyoda A, Misu S, Monma N, Ikeo K, Molina O, Vargiu G, Fujiyama A, Kimura H, Earnshaw WC, Fukagawa T. Histone H4 Lys 20 monomethylation of the CENP-A nucleosome is essential for kinetochore assembly. Dev Cell. 2014 Jun 23;29(6):740-9. doi: 10.1016/j.devcel.2014.05.001. PMID: 24960696; FREE ARTICLE

 

Booth DG, Takagi M, Sanchez-Pulido L, Petfalski E, Vargiu G, Samejima K, Imamoto N, Ponting CP, Tollervey D, Earnshaw WC, Vagnarelli P. Ki-67 is a PP1-interacting protein that organises the mitotic chromosome periphery. Elife. 2014 May 27;3:e01641. doi: 10.7554/eLife.01641. PMID: 24867636; FREE ARTICLE

 

Ribeiro SA, Vagnarelli P, Earnshaw WC. DNA content of a functioning chicken kinetochore. Chromosome Res. 2014 Apr;22(1):7-13. doi: 10.1007/s10577-014-9410-3. PMID: 24633498; FREE ARTICLE

 

Kouprina N, Tomilin AN, Masumoto H, Earnshaw WC, Larionov V. Human artificial chromosome-based gene delivery vectors for biomedicine and biotechnology. Expert Opin Drug Deliv. 2014 Apr;11(4):517-35. doi: 10.1517/17425247.2014.882314. Epub 2014 Jan 30. PMID: 24479793

 

Earnshaw WC. Deducing protein function by forensic integrative cell biology. PLoS Biol. 2013 Dec;11(12):e1001742. doi: 10.1371/journal.pbio.1001742. Epub 2013 Dec 17. PMID: 24358025; FREE ARTICLE

 

Kim JH, Zhang T, Wong NC, Davidson N, Maksimovic J, Oshlack A, Earnshaw WC, Kalitsis P, Hudson DF. Condensin I associates with structural and gene regulatory regions in vertebrate chromosomes. Nat Commun. 2013;4:2537. doi: 10.1038/ncomms3537. PMID: 24088984; FREE ARTICLE

 

Earnshaw WC, Cleveland DW. CENP-A and the CENP nomenclature: response to Talbert and Henikoff. Trends Genet. 2013 Sep;29(9):500-2. doi: 10.1016/j.tig.2013.06.008. Epub 2013 Aug 2. PMID: 23910159

 

Lee HS, Lee NC, Grimes BR, Samoshkin A, Kononenko AV, Bansal R, Masumoto H, Earnshaw WC, Kouprina N, Larionov V. A new assay for measuring chromosome instability (CIN) and identification of drugs that elevate CIN in cancer cells. BMC Cancer. 2013 May 22;13:252. doi: 10.1186/1471-2407-13-252. PMID: 23694679; FREE ARTICLE

 

Lee NC, Kononenko AV, Lee HS, Tolkunova EN, Liskovykh MA, Masumoto H, Earnshaw WC, Tomilin AN, Larionov V, Kouprina N. Protecting a transgene expression from the HAC-based vector by different chromatin insulators. Cell Mol Life Sci. 2013 Oct;70(19):3723-37. doi: 10.1007/s00018-013-1362-9. Epub 2013 May 16. PMID: 23677492; FREE ARTICLE

 

Earnshaw WC, Allshire RC, Black BE, Bloom K, Brinkley BR, Brown W, Cheeseman IM, Choo KH, Copenhaver GP, Deluca JG, Desai A, Diekmann S, Erhardt S, Fitzgerald-Hayes M, Foltz D, Fukagawa T, Gassmann R, Gerlich DW, Glover DM, Gorbsky GJ, Harrison SC, Heun P, Hirota T, Jansen LE, Karpen G, Kops GJ, Lampson MA, Lens SM, Losada A, Luger K, Maiato H, Maddox PS, Margolis RL, Masumoto H, McAinsh AD, Mellone BG, Meraldi P, Musacchio A, Oegema K, O'Neill RJ, Salmon ED, Scott KC, Straight AF, Stukenberg PT, Sullivan BA, Sullivan KF, Sunkel CE, Swedlow JR, Walczak CE, Warburton PE, Westermann S, Willard HF, Wordeman L, Yanagida M, Yen TJ, Yoda K, Cleveland DW. Esperanto for histones: CENP-A, not CenH3, is the centromeric histone H3 variant. Chromosome Res. 2013 Apr;21(2):101-6. doi: 10.1007/s10577-013-9347-y. Epub 2013 Apr 12. PMID: 23580138; FREE ARTICLE

 

Kononenko AV, Lee NC, Earnshaw WC, Kouprina N, Larionov V. Re-engineering an alphoid(tetO)-HAC-based vector to enable high-throughput analyses of gene function. Nucleic Acids Res. 2013 May 1;41(10):e107. doi: 10.1093/nar/gkt205. Epub 2013 Apr 4. PMID: 23558748; FREE ARTICLE

 

Shang WH, Hori T, Martins NM, Toyoda A, Misu S, Monma N, Hiratani I, Maeshima K, Ikeo K, Fujiyama A, Kimura H, Earnshaw WC, Fukagawa T. Chromosome engineering allows the efficient isolation of vertebrate neocentromeres. Dev Cell. 2013 Mar 25;24(6):635-48. doi: 10.1016/j.devcel.2013.02.009. Epub 2013 Mar 14. PMID: 23499358; FREE ARTICLE

 

Kouprina N, Samoshkin A, Erliandri I, Nakano M, Lee HS, Fu H, Iida Y, Aladjem M, Oshimura M, Masumoto H, Earnshaw WC, Larionov V. Organization of synthetic alphoid DNA array in human artificial chromosome (HAC) with a conditional centromere. ACS Synth Biol. 2012 Dec 21;1(12):590-601. PMID: 23411994; FREE ARTICLE

 

Tachiwana H, Miya Y, Shono N, Ohzeki J, Osakabe A, Otake K, Larionov V, Earnshaw WC, Kimura H, Masumoto H, Kurumizaka H. Nap1 regulates proper CENP-B binding to nucleosomes. Nucleic Acids Res. 2013 Mar 1;41(5):2869-80. doi: 10.1093/nar/gks1464. Epub 2013 Jan 15. PMID: 23325853; FREE ARTICLE

 

Carmena M, Wheelock M, Funabiki H, Earnshaw WC. The chromosomal passenger complex (CPC): from easy rider to the godfather of mitosis.Nat Rev Mol Cell Biol. 2012 Dec;13(12):789-803. doi: 10.1038/nrm3474. Review. PMID: 23175282; FREE ARTICLE

 

Samejima K, Samejima I, Vagnarelli P, Ogawa H, Vargiu G, Kelly DA, de Lima Alves F, Kerr A, Green LC, Hudson DF, Ohta S, Cooke CA, Farr CJ, Rappsilber J, Earnshaw WC. Mitotic chromosomes are compacted laterally by KIF4 and condensin and axially by topoisimerase IIa.J Cell Biol. 2012 Nov 26;199(5):755-70. doi: 10.1083/jcb.201202155. PMID: 23166350; FREE ARTICLE

 

Kouprina N, Earnshaw WC, Masumoto H, Larionov V. A new generation of human artificial chromosomes for functional genomics and gene therapy. Cell Mol Life Sci. 2013 Apr;70(7):1135-48. doi: 10.1007/s00018-012-1113-3. Epub 2012 Aug 21. Review. PMID: 22907415; FREE ARTICLE

 

Bergmann JH, Martins NM, Larionov V, Masumoto H, Earnshaw WC. HACking the centromere chromatin code: insights from human artificial chromosomes. Chromosome Res. 2012 Jul; 20(5):505-19. doi: 10.1007/s10577-012-9293-0. Review. PMID: 22825423.

 

Ohzeki JI, Bergmann JH, Kouprina N, Noskov VN, Nakano M, Kimura H, Earnshaw WC, Larionov V, Masumoto H. Breaking the HAC Barrier: Histone H3K9 acetyl/methyl balance regulates CENP-A assembly. EMBO J. 2012 May 16;31(10):2391-402. doi: 10.1038/emboj.2012.82. Epub 2012 Apr 3.PubMed PMID: 22473132; FREE ARTICLE

 

Vagnarelli P, Earnshaw WC. Repo-Man-PP1: a link between chromatin remodelling and nuclear envelope reassembly. Nucleus. 2012 Mar 1;3(2):138-42. doi: 10.4161/nucl.19267. Epub 2012 Mar 1. Review. PMID: 22555598; FREE ARTICLE

 

Green LC, Kalitsis P, Chang TM, Cipetic M, Kim JH, Marshall O, Turnbull L, Whitchurch CB, Vagnarelli P, Samejima K, Earnshaw WC, Choo KH, Hudson DF. Contrasting roles of condensin I and II in mitotic chromosome formation. J Cell Sci. 2012 Mar 15;125(Pt 6):1591-1604. Epub 2012 Feb 17. PubMed PMID: 22344259.

 

Bergmann JH, Jakubsche JN, Martins NM, Kagansky A, Nakano M, Kimura H, Kelly DA, Turner BM, Masumoto H, Larionov V, Earnshaw WC. Epigenetic engineering: histone H3K9 acetylation is compatible with kinetochore structure and function. J Cell Sci. 2012 Jan 15;125(Pt 2):411-21. Epub 2012 Feb 13. PubMed PMID: 22331359.

 

Carmena M, Pinson X, Platani M, Salloum Z, Xu Z, Clark A, Macisaac F, Ogawa H, Eggert U, Glover DM, Archambault V, Earnshaw WC. The chromosomal passenger complex activates Polo kinase at centromeres. PLoS Biol. 2012 Jan;10(1):e1001250. Epub 2012 Jan 24. PubMed PMID: 22291575FREE ARTICLE

 

Kim JH, Kononenko A, Erliandri I, Kim TA, Nakano M, Iida Y, Barrett JC, Oshimura M, Masumoto H, Earnshaw WC, Larionov V, Kouprina N. Human artificial chromosome (HAC) vector with a conditional centromere for correction of genetic deficiencies in human cells. Proc Natl Acad Sci U S A. 2011 Dec 13;108(50):20048-53. Epub 2011 Nov 28. PubMed PMID: 22123967FREE ARTICLE

 

Flors C, Earnshaw WC. Super-resolution fluorescence microscopy as a tool to study the nanoscale organization of chromosomes. Curr Opin Chem Biol. 2011 Dec;15(6):838-44. Epub 2011 Nov 16. Review. PubMed PMID: 22098720.

 

Vagnarelli P, Ribeiro S, Sennels L, Sanchez-Pulido L, de Lima Alves F, Verheyen T, Kelly DA, Ponting CP, Rappsilber J, Earnshaw WC. Repo-Man coordinates chromosomal reorganization with nuclear envelope reassembly during mitotic exit. Dev Cell. 2011 Aug 16;21(2):328-42. Epub 2011 Aug 4. PubMed PMID: 21820363.

 

Ohta S, Bukowski-Wills JC, Wood L, de Lima Alves F, Chen Z, Rappsilber J, Earnshaw WC. Proteomics of isolated mitotic chromosomes identifies the kinetochore protein Ska3/Rama1. Cold Spring Harb Symp Quant Biol. 2010;75:433-8. Epub 2011 Feb 2. PubMed PMID: 21289047.

 

Bergmann JH, Rodriguez MG, Martins NM, Kimura H, Kelly DA, Masumoto H, Larionov V, Jansen LE, Earnshaw WC. Epigenetic engineering shows H3K4me2 is required for HJURP targeting and CENP-A assembly on a synthetic human kinetochore. EMBO J. 2011 Jan 19;30(2):328-40. Epub 2010 Dec 14. PubMed PMID: 21157429FREE ARTICLE

 

Fant X, Samejima K, Carvalho A, Ogawa H, Xu Z, Yue Z, Earnshaw WC, Ruchaud S. Use of DT40 conditional-knockout cell lines to study chromosomal passenger protein function. Biochem Soc Trans. 2010 Dec;38(6):1655-9. PubMed PMID: 21118143.

 

Ohta S, Wood L, Bukowski-Wills JC, Rappsilber J, Earnshaw WC. Building mitotic chromosomes. Curr Opin Cell Biol. 2011 Feb;23(1):114-21. Epub 2010 Oct 23. Review. PubMed PMID: 20974528; FREE ARTICLE

 

Xu Z, Vagnarelli P, Ogawa H, Samejima K, Earnshaw WC. Gradient of increasing  Aurora B kinase activity is required for cells to execute mitosis. J Biol Chem. 2010 Dec 17;285(51):40163-70. Epub 2010 Oct 18. PubMed PMID: 20956539; FREE ARTICLE

 

Ohta S, Bukowski-Wills JC, Sanchez-Pulido L, Alves Fde L, Wood L, Chen ZA, Platani M, Fischer L, Hudson DF, Ponting CP, Fukagawa T, Earnshaw WC, Rappsilber J. The protein composition of mitotic chromosomes determined using multiclassifier combinatorial proteomics. Cell. 2010 Sep 3;142(5):810-21. PubMed PMID: 20813266; FREE ARTICLE

 

Iida Y, Kim JH, Kazuki Y, Hoshiya H, Takiguchi M, Hayashi M, Erliandri I, Lee
HS, Samoshkin A, Masumoto H, Earnshaw WC, Kouprina N, Larionov V, Oshimura M. Human artificial chromosome with a conditional centromere for gene delivery and gene expression. DNA Res. 2010 Oct;17(5):293-301. Epub 2010 Aug 26. PubMed PMID: 20798231; FREE ARTICLE

 

Fernandez-Miranda G, Perez de Castro I, Carmena M, Aguirre-Portoles C, Ruchaud S, Fant X, Montoya G, Earnshaw WC, Malumbres M. SUMOylation modulates the function of Aurora-B kinase. J Cell Sci. 2010 Aug 15;123(Pt 16):2823-33. Epub 2010 Jul 27. PubMed PMID: 20663916; FREE ARTICLE

 

Ribeiro SA, Vagnarelli P, Dong Y, Hori T, McEwen BF, Fukagawa T, Flors C, Earnshaw WC. A super-resolution map of the vertebrate kinetochore. Proc Natl Acad Sci U S A. 2010 Jun 8;107(23):10484-9. Epub 2010 May 18. PubMed PMID: 20483991; FREE ARTICLE

 

Patzlaff JS, Terrenoire E, Turner BM, Earnshaw WC, Paulson JR. Acetylation of core histones in response to HDAC inhibitors is diminished in mitotic HeLa cells. Exp Cell Res. 2010 Aug 1;316(13):2123-35. Epub 2010 May 7. PubMed PMID: 20452346; FREE ARTICLE

 

Xu Z, Ogawa H, Vagnarelli P, Bergmann JH, Hudson DF, Ruchaud S, Fukagawa T, Earnshaw WC, Samejima K. INCENP-aurora B interactions modulate kinase activity and chromosome passenger complex localization. J Cell Biol. 2009 Nov 30;187(5):637-53. Erratum in: J Cell Biol. 2010 Feb 22;188(4):611. PubMed PMID: 19951914; FREE ARTICLE

 

Carmena M, Ruchaud S, Earnshaw WC. Making the Auroras glow: regulation of Aurora A and B kinase function by interacting proteins. Curr Opin Cell Biol. 2009 Dec;21(6):796-805. Review. PubMed PMID: 19836940; FREE ARTICLE

 

Cardinale S, Bergmann JH, Kelly D, Nakano M, Valdivia MM, Kimura H, Masumoto  H, Larionov V, Earnshaw WC. Hierarchical inactivation of a synthetic human kinetochore by a chromatin modifier. Mol Biol Cell. 2009 Oct;20(19):4194-204. Epub 2009 Aug 5. PubMed PMID: 19656847; FREE ARTICLE

 

Hudson DF, Marshall KM, Earnshaw WC. Condensin: Architect of mitotic chromosomes. Chromosome Res. 2009;17(2):131-44. Review. PubMed PMID: 19308696.

 

Ribeiro SA, Gatlin JC, Dong Y, Joglekar A, Cameron L, Hudson DF, Farr CJ, McEwen BF, Salmon ED, Earnshaw WC, Vagnarelli P. Condensin regulates the stiffness of vertebrate centromeres. Mol Biol Cell. 2009 May;20(9):2371-80. Epub 2009 Mar 4. PubMed PMID: 19261808; FREE ARTICLE

 

Zhou L, Li J, George R, Ruchaud S, Zhou HG, Ladbury JE, Earnshaw WC, Yuan X.  Effects of full-length borealin on the composition and protein-protein interaction activity of a binary chromosomal passenger complex. Biochemistry. 2009 Feb 17;48(6):1156-61. PubMed PMID: 19146389; FREE ARTICLE

 

Yue Z, Carvalho A, Xu Z, Yuan X, Cardinale S, Ribeiro S, Lai F, Ogawa H, Gudmundsdottir E, Gassmann R, Morrison CG, Ruchaud S, Earnshaw WC. Deconstructing Survivin: comprehensive genetic analysis of Survivin function by conditional knockout in a vertebrate cell line. J Cell Biol. 2008 Oct 20;183(2):279-96. PubMed PMID: 18936249; FREE ARTICLE

 

Tadeu AM, Ribeiro S, Johnston J, Goldberg I, Gerloff D, Earnshaw WC. CENP-V is required for centromere organization, chromosome alignment and cytokinesis. EMBO J. 2008 Oct 8;27(19):2510-22. Epub 2008 Sep 4. PubMed PMID: 18772885; FREE ARTICLE

 

Colombie N, Cullen CF, Brittle AL, Jang JK, Earnshaw WC, Carmena M, McKim K, Ohkura H. Dual roles of Incenp crucial to the assembly of the acentrosomal metaphase spindle in female meiosis. Development. 2008 Oct;135(19):3239-46. Epub 2008 Aug 28. PubMed PMID: 18755775; FREE ARTICLE

 

Hudson DF, Ohta S, Freisinger T, Macisaac F, Sennels L, Alves F, Lai F, Kerr A, Rappsilber J, Earnshaw WC. Molecular and genetic analysis of condensin function in vertebrate cells. Mol Biol Cell. 2008 Jul;19(7):3070-9. Epub 2008 May 14. PubMed PMID: 18480406; FREE ARTICLE

 

Vagnarelli P, Ribeiro SA, Earnshaw WC. Centromeres: old tales and new tools. FEBS Lett. 2008 Jun 18;582(14):1950-9. Epub 2008 Apr 22. Review. PubMed PMID: 18435926.

 

Nakano M, Cardinale S, Noskov VN, Gassmann R, Vagnarelli P, Kandels-Lewis S, Larionov V, Earnshaw WC, Masumoto H. Inactivation of a human kinetochore by specific targeting of chromatin modifiers. Dev Cell. 2008 Apr;14(4):507-22. PubMed PMID: 18410728; FREE ARTICLE

 

Kaufmann SH, Lee SH, Meng XW, Loegering DA, Kottke TJ, Henzing AJ, Ruchaud S, Samejima K, Earnshaw WC. Apoptosis-associated caspase activation assays. Methods. 2008 Mar;44(3):262-72. Review. PubMed PMID: 18314058.

 

Samejima K, Ogawa H, Cooke CA, Hudson DF, Macisaac F, Ribeiro SA, Vagnarelli P, Cardinale S, Kerr A, Lai F, Ruchaud S, Yue Z, Earnshaw WC. A promoter-hijack strategy for conditional shutdown of multiply spliced essential cell cycle genes. Proc Natl Acad Sci U S A. 2008 Feb 19;105(7):2457-62. Epub 2008 Feb 8. Erratum in: Proc Natl Acad Sci U S A. 2008 Apr 8;105(14):5650. Hudson, Damien [Hudson, Damien F]. PubMed PMID: 18263736; FREE ARTICLE

 

Griffith E, Walker S, Martin CA, Vagnarelli P, Stiff T, Vernay B, Al Sanna N, Saggar A, Hamel B, Earnshaw WC, Jeggo PA, Jackson AP, O'Driscoll M. Mutations in pericentrin cause Seckel syndrome with defective ATR-dependent DNA damage signaling. Nat Genet. 2008 Feb;40(2):232-6. Epub 2007 Dec 23. PubMed PMID: 18157127; FREE ARTICLE

 

Ruchaud S, Carmena M, Earnshaw WC. The chromosomal passenger complex: one for all and all for one. Cell. 2007 Oct 19;131(2):230-1. PubMed PMID: 17956723.

 

Ruchaud S, Carmena M, Earnshaw WC. Chromosomal passengers: conducting cell division. Nat Rev Mol Cell Biol. 2007 Oct;8(10):798-812. Review. PubMed PMID: 17848966.

 

Tone S, Sugimoto K, Tanda K, Suda T, Uehira K, Kanouchi H, Samejima K, Minatogawa Y, Earnshaw WC. Three distinct stages of apoptotic nuclear condensation revealed by time-lapse imaging, biochemical and electron microscopy analysis of cell-free apoptosis. Exp Cell Res. 2007 Oct 1;313(16):3635-44. Epub 2007 Jul 4. PubMed PMID: 17643424; FREE ARTICLE

 

Ageichik AV, Samejima K, Kaufmann SH, Earnshaw WC. Genetic analysis of the short splice variant of the inhibitor of caspase-activated DNase (ICAD-S) in chicken DT40 cells. J Biol Chem. 2007 Sep 14;282(37):27374-82. Epub 2007 Jul 6. PubMed PMID: 17616520. FREE ARTICLE

 

Faragher AJ, Sun XM, Butterworth M, Harper N, Mulheran M, Ruchaud S, Earnshaw WC, Cohen GM. Death receptor-induced apoptosis reveals a novel interplay between the chromosomal passenger complex and CENP-C during interphase. Mol Biol Cell. 2007 Apr;18(4):1337-47. Epub 2007 Feb 7. PubMed PMID: 17287400; FREE ARTICLE

 

Zachos G, Black EJ, Walker M, Scott MT, Vagnarelli P, Earnshaw WC, Gillespie DA. Chk1 is required for spindle checkpoint function. Dev Cell. 2007 Feb;12(2):247-60. PubMed PMID: 17276342.

 

Rodriguez-Bayona B, Ruchaud S, Rodriguez C, Linares M, Astola A, Ortiz M, Earnshaw WC, Valdivia MM. Autoantibodies against the chromosomal passenger protein INCENP found in a patient with Graham Little-Piccardi-Lassueur syndrome.  J Autoimmune Dis. 2007 Jan 12;4:1. PubMed PMID: 17222351; FREE ARTICLE

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